Structure, regulation and related diseases of the actin-binding protein gelsolin.
Jessica FeldtMartin SchichtFabian GarreisJessica WelssUlrich W SchneiderFriedrich PaulsenPublished in: Expert reviews in molecular medicine (2019)
Gelsolin (GSN), one of the most abundant actin-binding proteins, is involved in cell motility, shape and metabolism. As a member of the GSN superfamily, GSN is a highly structured protein in eukaryotic cells that can be regulated by calcium concentration, intracellular pH, temperature and phosphatidylinositol-4,5-bisphosphate. GSN plays an important role in cellular mechanisms as well as in different cellular interactions. Because of its participation in immunologic processes and its interaction with different cells of the immune system, GSN is a potential candidate for various therapeutic applications. In this review, we summarise the structure of GSN as well as its regulating and functional roles, focusing on distinct diseases such as Alzheimer's disease, rheumatoid arthritis and cancer. A short overview of GSN as a therapeutic target in today's medicine is also provided.
Keyphrases
- induced apoptosis
- rheumatoid arthritis
- binding protein
- cell cycle arrest
- physical activity
- single cell
- endoplasmic reticulum stress
- disease activity
- cell therapy
- signaling pathway
- small molecule
- young adults
- staphylococcus aureus
- biofilm formation
- amino acid
- systemic sclerosis
- transcription factor
- bone marrow
- cell proliferation
- protein kinase
- pseudomonas aeruginosa
- systemic lupus erythematosus
- reactive oxygen species
- ankylosing spondylitis
- candida albicans