Systemic Inflammatory Markers Combined with Tumor-Infiltrating Lymphocyte Density for the Improved Prediction of Response to Neoadjuvant Chemoradiotherapy in Rectal Cancer.
Ryuichiro SawadaTakashi AkiyoshiYusuke KitagawaYukiharu HiyoshiToshiki MukaiToshiya NagasakiTomohiro YamaguchiTsuyoshi KonishiNoriko YamamotoMasashi UenoYosuke FukunagaPublished in: Annals of surgical oncology (2021)
LCR, N × M value, and CD8+ TIL density are independently associated with response to CRT. Assessing local TIL density along with systemic inflammatory markers may be useful for selecting a multimodal neoadjuvant approach in rectal cancer therapy.