Impact of COVID-19 vaccination on symptoms and immune phenotypes in vaccine-naïve individuals with Long COVID.
Connor B GradyBornali BhattacharjeeJulio SilvaJillian JaycoxLik Wee LeeValter Silva MonteiroMitsuaki SawanoDaisy MasseyCésar CaraballoJeff R GehlhausenAlexandra TabachnikovaTianyang MaoCarolina LucasMario A Peña-HernandezLan XuTiffany J TzengTakehiro TakahashiJeph HerrinDiana Berrent GütheAthena AkramiGina AssafHannah DavisKaren HarrisLisa McCorkellWade L SchulzDaniel GrffinHannah WeiAaron M RingLeying GuanCharles Dela CruzAkiko IwasakiHarlan M KrumholzPublished in: medRxiv : the preprint server for health sciences (2024)
The impact of the COVID-19 vaccine on vaccine-naïve individuals suffering from Long COVID is uncertain. This study assessed the experience and immune signatures of 16 unvaccinated participants with Long COVID. A total of 10 participants had improved health status after vaccination, and one person reported only worsening health. As expected, vaccination increased immune cells and antibodies against the viral spike protein. Immune signatures may prove to be predictors of health status after vaccination. However, given the small number of participants, these initial findings need further validation.