Metabolic Syndrome Alters the Cargo of Mitochondria-Related microRNAs in Swine Mesenchymal Stem Cell-Derived Extracellular Vesicles, Impairing Their Capacity to Repair the Stenotic Kidney.

Rahele A FarahaniXiang-Yang ZhuHui TangKyra L JordanAmir LermanLilach O LermanAlfonso Eirin

Published in: Stem cells international (2020)

MetS alters the cargo of mitochondria-related microRNAs in swine MSC-derived EVs, which might impair their capacity to repair the poststenotic kidney in MetS+RAS. These observations may contribute to develop approaches to improve the efficacy of MSC-EVs for patients with MetS.

Keyphrases

metabolic syndrome
mesenchymal stem cells
cell death
reactive oxygen species
bone marrow
insulin resistance
type diabetes
stem cells
adipose tissue
cell therapy
umbilical cord