SCpRh(III)-Catalyzed Asymmetric C-H Trifluoromethylalkylation of N -Methoxybenzamides with β- Trifluoromethyl-α,β-Unsaturated Ketones.

Asymmetric C-H trifluoromethylalkylation represents a novel and straightforward synthetic method for the construction of chiral CF 3 -containing compounds. However, the reported examples remain limited, given the challenges of reactivity and enantioselective control. Herein, we report a SCpRh(III)-catalyzed asymmetric aryl and alkenyl C-H trifluoromethylalkylation reaction with β-trifluoromethyl-α,β-unsaturated ketones. The chiral CF 3 -bearing adducts were obtained in moderate to good yields with high enantioselectivity (up to 81% yield and 96% ee). The reaction features mild conditions and broad substrate scope. The chiral CF 3 -bearing products could undergo diverse functional group transformations.