Metabolic responses to exogenous ghrelin in obesity and early after Roux-en-Y gastric bypass in humans.

Robyn A TamboliJoseph AntounReem M SidaniAustin ClementsEmily E HarmataPam Marks-ShulmanBruce D GaylinnBrandon WilliamsRonald H ClementsVance L AlbaughNaji N Abumrad

Published in: Diabetes, obesity & metabolism (2017)

These data suggest that obesity is characterized by abnormal central, but not peripheral, responsiveness to ghrelin that can be restored early after RYGB before significant weight loss. Further work is necessary to fully elucidate the role of ghrelin in the metabolic changes that occur in obesity and following RYGB.

Keyphrases

weight loss
roux en y gastric bypass
bariatric surgery
gastric bypass
weight gain
obese patients
glycemic control
insulin resistance
metabolic syndrome
type diabetes
body mass index
high fat diet induced
growth hormone
machine learning
chemotherapy induced