Genetic architecture distinguishes systemic juvenile idiopathic arthritis from other forms of juvenile idiopathic arthritis: clinical and therapeutic implications.
Michael J OmbrelloVictoria L ArthurElaine F RemmersAnne HinksIoanna TachmazidouAlexei A GromDirk FoellAlberto MartiniMarco GattornoSeza ÖzenSampath PrahaladAndrew S ZeftJohn F BohnsackNorman T IlowiteElizabeth D MellinsRicardo RussoClaudio LenMaria Odete E HilarioSheila OliveiraRae S M YeungAlan M RosenbergLucy R WedderburnJordi AntonJohannes-Peter HaasAngela Rosen-WolffKirsten MindenKlaus TenbrockErkan DemirkayaJoanna CobbElizabeth BaskinSara SignaEmily ShuldinerRichard H DuerrJean-Paul AchkarM Ilyas KambohKenneth M KaufmanLeah C KottyanDalila PintoStephen W SchererMarta E Alarcón-RiquelmeElisa DocampoXavier EstivillAhmet Gülnull nullCarl D LangefeldSusan ThompsonEleftheria ZegginiDaniel L KastnerPatricia WooWendy ThomsonPublished in: Annals of the rheumatic diseases (2016)
The lack of shared genetic risk factors between sJIA and other JIA subtypes supports the hypothesis that sJIA is a unique disease process and argues for a different classification framework. Research to improve sJIA therapy should target its unique genetics and specific pathophysiological pathways.