Antibiofilm agents with therapeutic potential against enteroaggregative Escherichia coli.
David A KwasiChinedum P BabalolaOlujide O OlubiyiJennifer HoffmannIkemefuna C UzochukwuIruka N OkekePublished in: PLoS neglected tropical diseases (2022)
This study identified five compounds, not previously described as anti-adhesins or Gram-negative antibacterials, with significant EAEC antibiofilm activity. Molecule, MMV687800 targets the EAEC Aap. In vitro small-molecule inhibition of EAEC colonization opens a way to new therapeutic approaches against EAEC infection.