A neglected and emerging antimicrobial resistance gene encodes for a serine-dependent macrolide esterase.

Poonam DhindwalCharis ThompsonDaniel KosKoa PlanedinRicha JainMurray Jelinski Antonio C Ruzzini

Published in: Proceedings of the National Academy of Sciences of the United States of America (2023)

The discovery of unreported antimicrobial resistance genes (ARGs) remains essential. Here, we report the identification and preliminary characterization of an α/β-hydrolase that inactivates macrolides. This serine-dependent macrolide esterase co-occurs with emerging ARGs in the environment, animal microbiomes, and pathogens.

Keyphrases

antimicrobial resistance
antibiotic resistance genes
genome wide
bioinformatics analysis
genome wide identification
protein kinase
small molecule
copy number
high throughput
dna methylation
microbial community
multidrug resistant
gram negative