Enhanced elimination of betamethasone in dichorionic twin pregnancies.

Grazielle de Fátima Pinto RodriguesJhohann Richard de Lima BenziLuísa Helena de Castro MatosStella Felippe de FreitasMaria Paula MarquesRicardo de Carvalho CavalliElaine Christine Dantas MoisésGeraldo DuarteVera Lucia LanchoteAlessandra Cristina Marcolin

Published in: British journal of clinical pharmacology (2021)

Data from this study suggest that the presence of 2 foetoplacental units may increase the betamethasone metabolism by hepatic CYP3A4 and/or placental 11β-HSD2 enzymes. Pharmacokinetic-pharmacodynamic clinical studies are needed to investigate whether these betamethasone pharmacokinetic changes have clinical repercussions for the newborns and require dose adjustment in DC twin pregnancies.

Keyphrases

gestational age
preterm birth
pregnant women
electronic health record
dendritic cells
low birth weight
big data
machine learning
immune response
cord blood