Spinal Inhibitory Dysfunction in Patients With Painful or Painless Diabetic Neuropathy.

Anne WorthingtonAlise KaltenieceMaryam FerdousiLuca D'OnofrioShaishav DhageShazli AzmiClare AdamsonShaheen HamdyRayaz A MalikNigel A CalcuttAndrew G Marshall

Published in: Diabetes care (2021)

We suggest that loss or impairment of HRDD may help to identify a subpopulation of patients with painful diabetic neuropathy mediated by impaired spinal inhibitory systems who may respond optimally to therapies that target spinal or supraspinal mechanisms. Enhanced RDD in patients without pain may reflect engagement of spinal pain-suppressing mechanisms.

Keyphrases

spinal cord
chronic pain
neuropathic pain
end stage renal disease
type diabetes
pain management
ejection fraction
newly diagnosed
chronic kidney disease
oxidative stress
wound healing
social media
spinal cord injury
patient reported outcomes