Circulating tight-junction proteins are potential biomarkers for blood-brain barrier function in a model of neonatal hypoxic/ischemic brain injury.

Erik Axel AnderssonCarina MallardC Joakim Ek

Published in: Fluids and barriers of the CNS (2021)

Levels of circulating claudin-5 and occludin are increased after hypoxic/ischemic brain injuries and blood-brain barrier-impairment and have promise as early biomarkers for cerebral vascular dysfunction and as a tool for risk assessment of neonatal brain injuries.

Keyphrases

blood brain barrier
cerebral ischemia
brain injury
subarachnoid hemorrhage
risk assessment
resting state
oxidative stress
white matter
big data
functional connectivity
machine learning
multiple sclerosis
artificial intelligence