Mesenchymal stromal cells-derived extracellular vesicles reprogramme macrophages in ARDS models through the miR-181a-5p-PTEN-pSTAT5-SOCS1 axis.

Yue SuJohnatas Dutra SilvaDeclan DohertyDavid A SimpsonDaniel J WeissSara Rolandsson-EnesDaniel F McAuleyCecilia M O'KaneDerek P BrazilAnna D Krasnodembskaya

Published in: Thorax (2022)

miR-181a-PTEN-pSTAT5-SOCS1 axis is a novel pathway responsible for immunomodulatory effect of MSC EVs in ARDS.

Keyphrases

cell proliferation
acute respiratory distress syndrome
extracorporeal membrane oxygenation
pi k akt
mechanical ventilation
long non coding rna
bone marrow
long noncoding rna
signaling pathway