Single cell and lineage tracing studies reveal the impact of CD34 + cells on myocardial fibrosis during heart failure.
Luping DuXiaotong SunHui GongTing WangLiujun JiangChengchen HuangXiaodong XuZhoubin LiHongfei XuLiang MaWeidong LiTing ChenQingbo XuPublished in: Stem cell research & therapy (2023)
cells differentiating into fibroblasts largely account for cardiac fibrosis. These findings may provide novel insights for the pathogenesis of cardiac fibrosis and have further potential therapeutic implications for the heart failure.
Keyphrases
- heart failure
- left ventricular
- single cell
- induced apoptosis
- cell cycle arrest
- rna seq
- cardiac resynchronization therapy
- signaling pathway
- oxidative stress
- cell death
- atrial fibrillation
- high throughput
- liver fibrosis
- computed tomography
- magnetic resonance
- genome wide
- magnetic resonance imaging
- contrast enhanced
- pi k akt