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Characteristics of Real-World Metastatic Non-Small Cell Lung Cancer Patients Treated with Nivolumab and Pembrolizumab During the Year Following Approval.

Sean KhozinAmy P AbernethyNathan C NussbaumJizu ZhiMelissa D CurtisMelisa TuckerShannon E LeeDavid E LightAnala GossaiRachael A SorgAracelis Z TorresPayal PatelGideon Michael BlumenthalRichard Pazdur
Published in: The oncologist (2018)
Evidence gathered in conventional clinical trials used to assess safety and efficacy of new therapies is not necessarily generalizable to real-world patients receiving these drugs following regulatory approval. Real-world evidence derived from electronic health record data can yield complementary evidence to enable optimal clinical decisions. Examined here is a cohort of programmed cell death protein 1 inhibitor-treated metastatic non-small cell lung cancer patients in the first year following regulatory approval of these therapies in this indication. The analysis revealed how the real-world cohort differed from the clinical trial cohorts, which will inform which patients are underrepresented and warrant additional studies.
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