Novel Prehospital Phenotypes and Outcomes in Adult-Patients with Acute Disease.
Francisco Martin-RodríguezRaúl López-IzquierdoAncor Sanz-GarcíaCarlos Del Pozo VegasMiguel Ángel Castro VillamorAgustín Mayo-IscarJosé L Martín-ContyGuillermo José OrtegaPublished in: Journal of medical systems (2022)
An early identification of prehospital phenotypes may allow health care workers to speed up and improve patients' treatment. To determine emergency phenotypes by exclusively using prehospital clinical data, a multicenter, prospective, and observational ambulance-based study was conducted with a cohort of 3,853 adult patients treated consecutively and transferred with high priority from the scene to the hospital emergency department. Cluster analysis determined three clusters with highly different outcome scores and pathological characteristics. The first cluster presented a 30-day mortality after the index event of 45.9%. The second cluster presented a mortality of 26.3%, while mortality of the third cluster was 5.1%. This study supports the detection of three phenotypes with different risk stages and with different clinical, therapeutic, and prognostic considerations. This evidence could allow adapting treatment to each phenotype thereby helping in the decision-making process.
Keyphrases
- emergency department
- cardiac arrest
- emergency medical
- decision making
- end stage renal disease
- healthcare
- public health
- trauma patients
- newly diagnosed
- chronic kidney disease
- ejection fraction
- risk factors
- clinical trial
- liver failure
- prognostic factors
- intensive care unit
- metabolic syndrome
- cardiovascular disease
- skeletal muscle
- respiratory failure
- young adults
- patient reported outcomes
- extracorporeal membrane oxygenation
- insulin resistance
- drug induced
- loop mediated isothermal amplification
- bioinformatics analysis