Biomarkers for traumatic brain injury: a short review.
Marcela Usberti GutierreJoão Paulo Motta TellesLeonardo Christiaan WellingNícollas Nunes RabeloManoel Jacobsen TeixeiraEberval Gadelha FigueiredoPublished in: Neurosurgical review (2020)
Cellular response to TBI is a mixture of excitotoxicity, neuroinflammation, and cell death. Biomarkers that can track these lesions and inflammatory processes are being explored for their potential to provide objective measures in the evaluation of TBI, from prehospital care to rehabilitation. By understanding the pathways involved, we could be able to improve diagnostic accuracy, guide management, and prevent long-term disability. We listed some of the recent advances in this translational, intriguing, fast-growing field. Although the knowledge gaps are still significant, some markers are showing promising results and could be helping patients in the near future.
Keyphrases
- traumatic brain injury
- cell death
- healthcare
- end stage renal disease
- severe traumatic brain injury
- ejection fraction
- newly diagnosed
- cardiac arrest
- prognostic factors
- chronic kidney disease
- oxidative stress
- quality improvement
- risk assessment
- lipopolysaccharide induced
- cell proliferation
- current status
- cognitive impairment
- lps induced
- human health
- pi k akt
- health insurance