Abnormal expression of histone acetylases in CD8+ T cells of patients with severe aplastic anemia.
Weiwei QiYu ZhangYachen WangHuaquan WangRong FuZonghong ShaoPublished in: Journal of clinical laboratory analysis (2022)
Our findings suggest that EP300 and CREBBP are increased in CD8+ T cells of SAA patients and are correlated with disease severity. The imbalances in HATs and HDACs may play a role in activating CD8+ T cells to promote the immune pathogenesis of SAA.