Endogenous/Exogenous Nanovaccines Synergistically Enhance Dendritic Cell-Mediated Tumor Immunotherapy.
Yu ZhangQiang LiMeng DingWeijun XiuJingyang ShanLihui YuwenDongliang YangXuejiao SongGuangwen YangXiaodan SuYongbin MouZhaogang TengHeng DongPublished in: Advanced healthcare materials (2023)
Traditional dendritic cell (DC)-mediated immunotherapy is usually suppressed by weak immunogenicity in tumors and generally leads to unsatisfactory outcomes. Synergistic exogenous/endogenous immunogenic activation can provide an alternative strategy for evoking a robust immune response by promoting DC activation. Herein, Ti 3 C 2 MXene-based nanoplatforms (termed MXP) are prepared with high-efficiency near-infrared photothermal conversion and immunocompetent loading capacity to form endogenous/exogenous nanovaccines. Specifically, the immunogenic cell death of tumor cells induced by the photothermal effects of the MXP can generate endogenous danger signals and antigens release to boost vaccination for DC maturation and antigen cross-presentation. In addition, MXP can deliver model antigen ovalbumin (OVA) and agonists (CpG-ODN) as an exogenous nanovaccine (MXP@OC), which further enhances DC activation. Importantly, the synergistic strategy of photothermal therapy and DC-mediated immunotherapy by MXP significantly eradicates tumors and enhances adaptive immunity. Hence, the present work provides a two-pronged strategy for improving immunogenicity and killing tumor cells to achieve a favorable outcome in tumor patients.
Keyphrases
- dendritic cells
- immune response
- regulatory t cells
- cancer therapy
- cell death
- high efficiency
- end stage renal disease
- photodynamic therapy
- drug delivery
- newly diagnosed
- chronic kidney disease
- dna methylation
- ejection fraction
- peritoneal dialysis
- type diabetes
- gene expression
- patient reported outcomes
- cell proliferation
- case report
- signaling pathway
- metabolic syndrome
- cell cycle arrest
- weight loss
- glycemic control