Acquired drug resistance interferes with the susceptibility of prostate cancer cells to metabolic stress.
Jessica CatapanoMarcin LutyTomasz WróbelMaciej PudełekKatarzyna PiwowarczykSylwia Kędracka-KrokMaciej SiedlarZbigniew MadejaJarosław CzyżPublished in: Cellular & molecular biology letters (2022)
Collectively, our data identify the mechanisms that underlie the limited potential of metformin for the chemotherapy of drug-resistant tumors. Metformin can enhance the sensitivity of cancer cells to chemotherapy by inducing their metabolic decoupling/imbalance. However, the acquired chemoresistance of cancer cells impairs this effect, facilitates cellular adaptation to metabolic stress, and prompts the invasive front formation.