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The IGF2BP3/Notch/Jag1 pathway: A key regulator of hepatic stellate cell ferroptosis in liver fibrosis.

Xinmiao LiYifei LiWeizhi ZhangFeng JiangLifan LinYining WangLingling WuHan ZengJianjian Zheng
Published in: Clinical and translational medicine (2024)
A modifications promote HSC ferroptosis. IGF2BP3 inhibition facilitates ferroptosis in HSCs via the Hes1/GPX4 axis. IGF2BP3 deficiency inactivates Jag1/Notch1/3/Hes1 signalling pathway inactivation, leading to the decrease in GPX4, which contributes to HSC ferroptosis.
Keyphrases
  • cell death
  • liver fibrosis
  • pi k akt
  • binding protein
  • cell proliferation
  • growth hormone
  • single cell
  • cell therapy
  • transcription factor
  • signaling pathway
  • mesenchymal stem cells
  • replacement therapy
  • smoking cessation