Influence of Cation Transporters (OCTs and MATEs) on the Renal and Hepatobiliary Disposition of [11C]Metoclopramide in Mice.

Irene Hernández-LozanoSeverin MairingerMichael SaubererJohann StanekThomas FilipThomas WanekGiuliano CiarimboliNicolas TournierOliver Langer

Published in: Pharmaceutical research (2021)

Our results suggest a contribution of OCT1/2 to the kidney and liver uptake and of MATEs to the urinary excretion of [11C]metoclopramide in mice. Cation transporters may contribute, next to variability in the activity of metabolizing enzymes, to variability in metoclopramide pharmacokinetics and side effects.

Keyphrases

high fat diet induced
ionic liquid
optical coherence tomography
type diabetes
adipose tissue
insulin resistance
metabolic syndrome