Pharmacogenetic determinants of warfarin in the Indian population.

Shaik Mohammad Naushad Vijay Kumar Kutala Tajamul Hussain Salman A Alrokayan

Published in: Pharmacological reports : PR (2021)

CYP2C9*2, CYP2C9*3, VKORC1 -1639 G > A and CYP4F2 V433M are common; CYP2C9*4, CYP2C9*5, CYP2C9*11, and CYP2C9*14 variants are rare in Indian subjects. All the CYP2C9 variants are found to be damaging. DNase I footprint analysis provided the mechanistic rationale for the association of VKORC1 -1639 G > A with warfarin sensitivity.

Keyphrases

atrial fibrillation
copy number
venous thromboembolism
direct oral anticoagulants
oral anticoagulants
data analysis