Luminescent metal organic frameworks with recognition sites for detection of hypochlorite through energy transfer.
Lan GuoYuan LiuFengli QuZhe LiuRongmei KongGuang ChenWenjing FanLian XiaPublished in: Mikrochimica acta (2019)
A luminescent metal organic framework (LMOF) of type UiO-66-NH2 was chosen for specific and sensitive detection of trace levels of hypochlorite. Hypochlorite causes the quenching of the blue fluorescence of nano-UiO-66-NH2 (with excitation/emission maxima at 325/430 nm), and this finding forms the basis for a fluorometric assay for hypochlorite. The method overcomes disadvantages of conventional redox-probes which are interfered by oxidants with oxidation capability stronger than that of hypochlorite. Compared with other fluorescent probes for sensing hypochlorite, UiO-66-NH2 has a comparable detection limit of 0.3 μmol L-1 and a broad linearity relationship in the range of 1-8 μmol L-1. The probe was successfully applied to the detection of hypochlorite in complex water samples and living Hela cells. Graphical abstract Schematic representation of hypochlorite induced quenching of the blue fluorescence of nano-UiO-66-NH2 (with excitation/emission maxima at 325/430 nm) through energy transfer. It overcomes disadvantages of conventional redox-probes which are interfered by oxidants with oxidation capability stronger than that of hypochlorite.
Keyphrases
- metal organic framework
- energy transfer
- quantum dots
- sensitive detection
- loop mediated isothermal amplification
- living cells
- small molecule
- single molecule
- room temperature
- photodynamic therapy
- hydrogen peroxide
- risk assessment
- cell cycle arrest
- induced apoptosis
- mass spectrometry
- heavy metals
- oxidative stress
- cell death
- signaling pathway
- fluorescent probe
- high resolution
- molecularly imprinted
- electron transfer