Rhizopus-host interplay of disseminated mucormycosis in immunocompetent mice.
Amanda R Dos SantosThais Fernanda de Campos Fraga-SilvaDébora de F AlmeidaRodolfo F Dos SantosAngela C FinatoBárbara Casella AmorimMaria I AndradeCleverson T SoaresVanessa Soares LaraNara Lígia Martins AlmeidaOlavo S de ArrudaMaria Sp de ArrudaJames VenturiniPublished in: Future microbiology (2020)
Aim: To investigate the immune response of disseminated Ryzopus oryzae infection in immunocompetent mice. Methods: C57Bl/6, BALB/c and Swiss wild-type mice were intravenously infected with R. oryzae; the parameters of infection and immune response were determined. Transcriptional signature of Th17 immune response and infection in Il17ra-/- mice were also evaluated. Results: All mouse strains showed an initial spread of R. oryzae in the target tissues; however, after 30 days, C57Bl/6 and BALB/c mice showed an effective fungal clearance associated with specific production of IL-17 and IL-2. We also observed that 60% of Il17ra-/- mice succumbed to infection within 16 days. Conclusion: This study has established an immunocompetent model for disseminated mucormycosis and highlighted the role of IL-17 signaling in immunity against R. oryzae.