Genetic and phenotypic analysis of the causal relationship between aging and COVID-19.

Albert K Ying Ranran Zhai Timothy V PyrkovAnastasia V ShindyapinaMarco MariottiPeter O FedichevXia Shen Vadim N Gladyshev

Published in: Communications medicine (2021)

Our analysis suggests that the factors that accelerate aging lead to an increased COVID-19 risk and point to the importance of Notch signaling and B cells in both. Interventions that target these factors to reduce biological age may reduce the risk of COVID-19.

Keyphrases

coronavirus disease
sars cov
respiratory syndrome coronavirus
physical activity
genome wide
dna methylation