TCF7L2 Genetic Variation Augments Incretin Resistance and Influences Response to a Sulfonylurea and Metformin: The Study to Understand the Genetics of the Acute Response to Metformin and Glipizide in Humans (SUGAR-MGH).
Shylaja SrinivasanVarinderpal KaurBindu ChamarthiKatherine R LittletonLing ChenAlisa K ManningJordi MerinoMelissa K ThomasMargo HudsonAllison GoldfineJose C FlorezPublished in: Diabetes care (2018)
Our findings demonstrate that common variation at TCF7L2 influences acute responses to both glipizide and metformin in people without diabetes and highlight altered incretin signaling as a potential mechanism by which TCF7L2 variation increases T2D risk.