Immunogenetic predisposing factors for mesial temporal lobe epilepsy with hippocampal sclerosis.
Bárbara LealJoão ChavesCláudia CarvalhoAndreia BettencourtCláudia BritoDaniela BoleixaJoel FreitasSandra BrásJoão LopesJoão RamalheiraPaulo P CostaBerta Martins da SilvaAntónio Martins da SilvaPublished in: The International journal of neuroscience (2018)
The rs16944 TT genotype is associated with MTLE-HS development what may be explained by the higher IL-1β levels produced by this genotype. High IL-1β levels may have neurotoxic effects or imbalance neurotransmission leading to seizures.