Rosinidin Protects Streptozotocin-Induced Memory Impairment-Activated Neurotoxicity by Suppressing Oxidative Stress and Inflammatory Mediators in Rats.
Khalid Saad AlharbiMuhammad AfzalSami I AlzareaShah Alam KhanFadhel Ahmed AlomarImran KazmiPublished in: Medicina (Kaunas, Lithuania) (2022)
Background and Objectives : To assess the antioxidant and neuroprotective role of rosinidin on rat memory impairment that is induced by streptozotocin. Materials and Methods : Wistar rats were given an intraperitoneal (i.p) injection of streptozotocin (60 mg/kg) followed by treatment with rosinidin at selective doses (10 and 20 mg/kg) for 30 days. The behavioral parameters were estimated by Y-maze test and Morris water test. Biochemical parameters such as acetylcholinesterase (AChE), choline aacetyltransferase (ChAT), and nitric oxide, and antioxidants such as glutathione transferase (GSH), superoxide dismutase (SOD) IL-6, IL-10, Nrf2, and BDNF, were determined. Results : The study results revealed that rosinidin improved cognition by reverting the behavioral parameters. The treatment with rosinidin restored the antioxidant enzymes and inflammatory cytokines. Conclusions : From the results, it has been proven that rosinidin possesses antioxidant, anti-amnesic, and anti-inflammatory activity. Rosinidin improved the cognitive and behavioral deficits that were induced by streptozotocin. Furthermore, 20 mg/kg rosinidin was found to have strong protective action against streptozotocin-induced toxicity.
Keyphrases
- diabetic rats
- oxidative stress
- ischemia reperfusion injury
- dna damage
- induced apoptosis
- nitric oxide
- traumatic brain injury
- working memory
- single cell
- heat shock
- multiple sclerosis
- adipose tissue
- endothelial cells
- mild cognitive impairment
- ultrasound guided
- endoplasmic reticulum stress
- blood brain barrier
- cerebral ischemia
- subarachnoid hemorrhage
- smoking cessation