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Rapid Generation of Sustainable HER2-specific T-cell Immunity in Patients with HER2 Breast Cancer using a Degenerate HLA Class II Epitope Vaccine.

Keith L KnutsonMatthew S BlockNadine NortonCourtney L ErskineTimothy J HobdayAllan B DietzDouglas PadleyMichael P GustafsonDanell Puglisi-KnutsonToni Kay MangskauSaranya ChumsriAmylou C DueckLavakumar KaryampudiGlynn WilsonAmy C Degnim
Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2019)
Degenerate HLA-DR-based HER2 vaccines induce sustainable HER2-specific T cells and antibodies. Future studies, could evaluate whether vaccination during adjuvant treatment with trastuzumab-containing regimens improves patient outcomes.
Keyphrases
  • early stage
  • epidermal growth factor receptor
  • current status
  • combination therapy
  • case control
  • sensitive detection
  • smoking cessation
  • breast cancer risk