Stratifying Lung Adenocarcinoma Risk with Multi-ancestry Polygenic Risk Scores in East Asian Never-Smokers.
Batel BlechterXiaoyu WangJianxin ShiKouya ShiraishiJiyeon ChoiKeitaro MatsuoTzu-Yu ChenJuncheng DaiRayjean J HungKexin ChenXiao-Ou ShuYoung Tae KimParichoy Pal ChoudhuryJacob WilliamsMaria Teresa LandiDongxin LinWei ZhengZhihua YinBao SongI-Shou ChangYun-Chul Hongnull nullNilanjan ChaVerjeeOlga Y GorlovaChristopher I AmosHongbing ShenChao Agnes HsiungStephen J ChanockNathaniel RothmanTakashi KohnoQing LanHaoyu ZhangPublished in: medRxiv : the preprint server for health sciences (2024)
Our study underscores the poteneal of mule-ancestry PRS approaches to enhance LUAD risk straeficaeon in never-smokers, parecularly in EAS populaeons, and highlights the necessary scale of future research to uncover the geneec underpinnings of LUAD.
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