New Physico-Chemical Analysis of Magnesium-Doped Hydroxyapatite in Dextran Matrix Nanocomposites.
Daniela PredoiCarmen Steluta CiobanuSimona Liliana IconaruȘtefan ŢăluLiliana GhegoiuRobert Saraiva MatosHenrique Duarte da Fonseca FilhoRoxana TruscaPublished in: Polymers (2023)
The new magnesium-doped hydroxyapatite in dextran matrix (10MgHApD) nanocomposites were synthesized using coprecipitation technique. A spherical morphology was observed by scanning electron microscopy (SEM). The X-ray diffraction (XRD) characterization results show hydroxyapatite hexagonal phase formation. The element map scanning during the EDS analysis revealed homogenous distribution of constituent elements of calcium, phosphor, oxygen and magnesium. The presence of dextran in the sample was revealed by Fourier transform infrared (FTIR) spectroscopy. The antimicrobial activity of the 10MgHAPD nanocomposites was assessed by in vitro assays using Staphylococcus aureus ATCC 25923, Pseudomonas aeruginosa ATCC 27853, Streptococcus mutans ATCC 25175, Porphyromonas gingivalis ATCC 33277 and Candida albicans ATCC 10231 microbial strains. The results of the antimicrobial assays highlighted that the 10MgHApD nanocomposites presented excellent antimicrobial activity against all the tested microorganisms and for all the tested time intervals. Furthermore, the biocompatibility assays determined that the 10MgHApD nanocomposites did not exhibit any toxicity towards Human gingival fibroblast (HGF-1) cells.
Keyphrases
- electron microscopy
- candida albicans
- biofilm formation
- staphylococcus aureus
- visible light
- pseudomonas aeruginosa
- reduced graphene oxide
- carbon nanotubes
- high resolution
- high throughput
- quantum dots
- escherichia coli
- tissue engineering
- endothelial cells
- induced apoptosis
- highly efficient
- magnetic resonance
- mass spectrometry
- induced pluripotent stem cells
- acinetobacter baumannii
- crystal structure
- high density