Dopamine metabolism by a monoamine oxidase mitochondrial shuttle activates the electron transport chain.

Steven M GravesZhong XieKristen A StoutEnrico ZampeseLena F BurbullaJean C ShihJyothisri KondapalliTommaso PatriarchiLin TianLars BrichtaPaul GreengardDimitri KraincPaul T SchumackerDalton James Surmeier

Published in: Nature neuroscience (2019)

Monoamine oxidase (MAO) metabolizes cytosolic dopamine (DA), thereby limiting auto-oxidation, but is also thought to generate cytosolic hydrogen peroxide (H2O2). We show that MAO metabolism of DA does not increase cytosolic H2O2 but leads to mitochondrial electron transport chain (ETC) activity. This is dependent upon MAO anchoring to the outer mitochondrial membrane and shuttling electrons through the intermembrane space to support the bioenergetic demands of phasic DA release.

Keyphrases

hydrogen peroxide
oxidative stress
nitric oxide
uric acid
metabolic syndrome
prefrontal cortex