Prevalent landscape of tumor genomic alterations of luminal B1 breast cancers using a comprehensive genomic profiling assay in Taiwan.

Bo-Fang ChenYi-Fang TsaiPei-Ju LienYen-Shu LinChin-Jung FengYen-Jen ChenHan-Fang ChengChun-Yu LiuTa-Chung ChaoJiun-I LaiLing-Ming TsengChi-Cheng Huang

Published in: Breast cancer (Tokyo, Japan) (2023)

PIK3CA, FGFR1, and BRCA1/2 were the most prevalent actionable alterations among Taiwanese luminal B1 breast cancer. Moreover, PTEN and BRCA1/2 was significantly associated with disease relapse.

Keyphrases

breast cancer risk
copy number
single cell
high throughput
cell proliferation
pi k akt
free survival
gene expression
dna methylation
protein kinase
genome wide
young adults