Alterations of Proximal Tubular Secretion in Autosomal Dominant Polycystic Kidney Disease.
Ke WangLeila R ZelnickYan ChenAndrew N HoofnagleTerry WatnickStephen SeligerBryan KestenbaumPublished in: Clinical journal of the American Society of Nephrology : CJASN (2019)
Patients with ADPKD and preserved and reduced GFR demonstrate lower tubular secretory solute excretion compared with healthy controls and patients with non-ADPKD CKD. Our results suggest that tubular secretion is impaired in ADPKD independent of GFR.