Identification of Key Genes of Human Advanced Diabetic Nephropathy Independent of Proteinuria by Transcriptome Analysis.

Fanghao Cai Xu-Jie ZhouYan JiaWeijian YaoJicheng LvGang Liu Li Yang

Published in: BioMed research international (2020)

Our study identified pathways including fibrosis, inflammation, lipid metabolism, and oxidative stress contributing to the progression of DN independent of proteinuria. These genes may serve as biomarkers and therapeutic targets.

Keyphrases

diabetic nephropathy
oxidative stress
bioinformatics analysis
genome wide
endothelial cells
genome wide identification
dna damage
ischemia reperfusion injury
induced apoptosis
diabetic rats
induced pluripotent stem cells
transcription factor