Phenolic components from the fruits of Solanum xanthocarpum with anti-inflammatory activity.

Two new compounds ( 1 and 2 ), along with thirty-one known compounds ( 3 - 33 ) were isolated from the fruits of Solanum xanthocarpum . The structure of isolates was elucidated by analysis of spectroscopic data and the physicochemical methods. Meanwhile, the anti-inflammatory activity of isolates was determined using LPS-induced RAW 264.7 cells. The results of anti-inflammatory assays indicated that most isolated compounds ( 3, 4 , 6 , 8 - 14 , 17-20 , and 30 ) possessed significant nitric oxide (NO) production inhibition in lipopolysaccharide (LPS)-induced RAW 264.7 cells with IC 50 values ranging from 14.33 to 48.55  μ M.