Carvacryl acetate, a novel semisynthetic monoterpene ester, binds to the TRPA1 receptor and is effective in attenuating irinotecan-induced intestinal mucositis in mice.
Elenice M AlvarengaNayara A SousaSimone de AraújoJosé L P JúniorAlyne R AraújoBruno IlesDvison M PacíficoGerly Anne C BritoEmmanuel P SouzaDamião Pergentino de SousaJand Venes Rolim MedeirosPublished in: The Journal of pharmacy and pharmacology (2017)
Carvacryl acetate is a promising anti-inflammatory and antioxidant agent, a fact confirmed through observations of its interactions with TRPA1 in CPT-11-induced intestinal mucositis in mice.