Escaping the Long Shadow Cast by Agranulocytosis: Reflections on Clozapine Pharmacovigilance Focused on the United Kingdom.
Jose De LeonManuel ArrojoHélène VerdouxCan-Jun RuanGeorgios SchoretsanitisChristopher RohdeDan CohenPeter F J SchulteSe Hyun KimRobert O CotesJonathan G LeungYuji OtsukaOleg O KirilochevTrino BaptistaSandeep GroverSusanna Every-PalmerScott Richard ClarkIan R McGraneMariano MotucaIsmael OlmosAlina WilkowskaMarina ŠagudAyşe Elif Anil YağcioğluDragana Ignjatovic RisticJudit LazaryEmílio J SanzCarlos De Las CuevasPublished in: Journal of clinical psychopharmacology (2023)
The interpretation of fatal outcomes in each country using pharmacovigilance databases is limited and only allows gross comparisons; even with those limitations, the UK data seem concerning. Pneumonia and myocarditis may be more important than agranulocytosis in explaining the uneven distribution of fatal outcomes in clozapine patients across countries.