Transcriptome changes induced in vitro by alcohol-containing mouthwashes in normal and dysplastic oral keratinocytes.

Simon A FoxSean S CurrieAndrew J DalleyCamile S Farah

Published in: Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology (2018)

Alcohol-containing mouthwashes are genotoxic in vitro to normal and dysplastic oral keratinocytes and induce widespread changes in gene expression. Dysplastic cells are more susceptible to the transcriptomic effects of mouthwash.

Keyphrases

gene expression
single cell
induced apoptosis
rna seq
dna methylation
alcohol consumption
cell cycle arrest
high glucose
wound healing
diabetic rats
genome wide
drug induced
signaling pathway
pi k akt