The cytotoxic properties of zinc oxide nanoparticles on the rat liver and spleen, and its anticancer impacts on human liver cancer cell lines.

Ghasem Rahimi Kalateh Shah MohammadSeyed Mohammad Reza SeyediEhsan Karimi Masoud Homayouni Tabrizi

Published in: Journal of biochemical and molecular toxicology (2019)

In general, in the current study, the antitumor effects of ZnO-NPs were confirmed by the enhancement of P53 and Bax genes expression profile, which are indicated the apoptotic induction in HUH7 cell line. Moreover, we introduced a safe-clinical ZnO-NPs dosage, have antitumor effects.

Keyphrases

oxide nanoparticles
room temperature
endothelial cells
quantum dots
cell death
reduced graphene oxide
oxidative stress
visible light
induced apoptosis
gene expression
gold nanoparticles
signaling pathway
endoplasmic reticulum stress
genome wide identification
transcription factor