Backbone chemical shift assignment of macrophage infectivity potentiator virulence factor of Trypanosoma cruzi.
Juan M LopezRicardo AntiparraGuy LippensMirko ZimicPatricia SheenHelena MaruendaPublished in: Biomolecular NMR assignments (2018)
Chagas disease is a trypanosomiasis disease inflicted by Trypanosoma cruzi parasite. In Latin America, at least 10 million people are infected and annually, 10,000 casualties are deplored. Macrophage infectivity potentiator protein is one of the major virulence factors secreted by T. cruzi (TcMIP) in order to infect its host but little is known about its mechanism of action. Studies confer TcMIP an important role in the extracellular matrix transmigration and basal lamina penetration. Here, we report the backbone 1H, 13C, and 15N resonance assignment of TcMIP and the comparison of the secondary structure obtained against reported X-ray crystallography data.
Keyphrases
- trypanosoma cruzi
- extracellular matrix
- pseudomonas aeruginosa
- escherichia coli
- staphylococcus aureus
- biofilm formation
- antimicrobial resistance
- adipose tissue
- electronic health record
- high resolution
- energy transfer
- big data
- protein protein
- case control
- binding protein
- amino acid
- magnetic resonance imaging
- mass spectrometry
- computed tomography
- artificial intelligence
- deep learning
- contrast enhanced
- clinical evaluation