Metabolic and mitochondrial dysregulation in CD4+ T cells from HIV-positive women on combination anti-retroviral therapy.
Matrona AkisoMagdalene AmekaKewreshini NaidooRobert K LangatJanet KomboDelories SikukuThumbi Ndung'uMarcus AltfeldOmu AnzalaMarianne Wanjiru MureithiPublished in: PloS one (2023)
Significant disparities in the utilization of substrates by leukocytes during chronic HIV/cART exist. Innate immune cells increased utilization of sugars and fats while adaptive immune cells displayed lower glucose and fat utilization despite having a higher mitochondrial activity. Our findings suggest that cART treated HIV-infected CD4+ T cells be dysfunctional or may prefer alternative fuel sources not included in these studies. This underscores the importance of understanding the metabolic effects of HIV treatment on immune function.
Keyphrases
- hiv positive
- antiretroviral therapy
- hiv infected
- human immunodeficiency virus
- men who have sex with men
- hiv aids
- south africa
- oxidative stress
- hiv testing
- immune response
- polycystic ovary syndrome
- adipose tissue
- peripheral blood
- stem cells
- drinking water
- metabolic syndrome
- blood glucose
- healthcare
- blood pressure
- case control
- insulin resistance
- type diabetes
- smoking cessation
- weight loss
- skeletal muscle
- bone marrow
- pregnancy outcomes