Multiomics Analysis of PCB126's Effect on a Mouse Chronic-Binge Alcohol Feeding Model.

Tyler C GripshoverBanrida WahlangKimberly Z HeadJianzhu LuoOluwanifemi E BolatimiMelissa L SmithEric C RouchkaJulia H CharikerJason XuLu CaiTimothy D CumminsMichael L MerchantHao ZhengMaiying KongMatthew C Cave

Published in: Environmental health perspectives (2024)

Previous work has demonstrated that PCB126 is a modifying factor in metabolic dysfunction-associated steatotic liver disease (MASLD), and our current work suggests that pollutants also modify ALD. PCB126 may, in part, be contributing to the malnutrition aspect of ALD, where metal deficiency is known to contribute and worsen prognosis. https://doi.org/10.1289/EHP14132.

Keyphrases

oxidative stress
heavy metals
alcohol consumption
replacement therapy
drug induced
anorexia nervosa