Modeling epistasis in mice and yeast using the proportion of two or more distinct genetic backgrounds: Evidence for "polygenic epistasis".
Christoph Daniel RauNatalia M GonzalesJoshua S BloomDanny S ParkJulien F AyrolesAbraham A PalmerAldons J LusisNoah A ZaitlenPublished in: PLoS genetics (2020)
Unlike our prior work in human populations, we observe widespread evidence of ancestry-modified SNP effects, perhaps reflecting the greater divergence present in crosses using mice and yeast.