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Crosslink between Temozolomide and PD-L1 immune-checkpoint inhibition in glioblastoma multiforme.

Sabrina HeynckesKaram DakaPamela FrancoAnnette GaebeleinJan Hendrik FrenkingRoberto Doria-MedinaIrina MaderDaniel DelevOliver SchnellDieter Henrik Heiland
Published in: BMC cancer (2019)
Our results suggest that TMZ therapy leads to a down-regulation of PD-L1 in primary GBM cells. These results support the clinical findings where PD-L1 is significantly reduced in recurrent GBMs. If the target is diminished, it may also lead to impaired efficacy of PD-1/PD-L1 inhibitors such as nivolumab.
Keyphrases
  • induced apoptosis
  • cell cycle arrest
  • oxidative stress
  • endoplasmic reticulum stress
  • bone marrow
  • cell therapy