Dual Axl/MerTK inhibitor INCB081776 creates a proinflammatory tumor immune microenvironment and enhances anti-PDL1 efficacy in head and neck cancer.

Kourtney L Kostecki Mari IidaAnne L WileyStanley KimaniBridget MehallKaitlin TetreaultRoxana AlexandridisMenggang YuSeungpyo HongRavi Salgia Justine Yang Bruce Raymond B Birge Paul M Harari Deric L Wheeler

Published in: Head & neck (2023)

This data indicates that simultaneous targeting of Axl and MerTK with INCB081776, either alone or in combination with anti-PDL1, slows tumor growth and creates a proinflammatory TIME in mouse models of HNC.

Keyphrases

tyrosine kinase
mouse model
stem cells
electronic health record
cancer therapy
big data
artificial intelligence