Molecular Alterations in Pediatric Fibroblastic/Myofibroblastic Tumors: An Appraisal of a Next Generation Sequencing Assay in a Retrospective Single Centre Study.

Jonathan C SlackMarie-Anne Bründler Erik W NohrJohn B McIntyreKyle C Kurek

Published in: Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society (2021)

We confirmed a significant subset of PFMTs remain difficult to classify using current criteria, and that a combined DNA/RNA assay can identify alterations in many of these cases, improving diagnostic certainty and suggesting a clinical utility for challenging cases.

Keyphrases

circulating tumor
high throughput
single molecule
nucleic acid
young adults
single cell
circulating tumor cells