Association of Rest-Activity Rhythm and Risk of Developing Dementia or Mild Cognitive Impairment in the Middle-Aged and Older Population: Prospective Cohort Study.
Shahab HaghayeghChenlu GaoElizabeth SuggXi ZhengHui-Wen YangRicha SaxenaMartin K RutterMichael N WeedonAgustin M IbanezDavid A BennettPeng LiLei GaoKun HuPublished in: JMIR public health and surveillance (2024)
Based on findings from a large sample of middle-to-older adults with objective RAR assessment and almost 8-years of follow-up, we suggest that suppressed and fragmented daily activity rhythms precede the onset of dementia or MCI and may serve as risk biomarkers for preclinical dementia in middle-aged and older adults.