Sinusoidal obstruction syndrome/veno-occlusive disease: current situation and perspectives-a position statement from the European Society for Blood and Marrow Transplantation (EBMT).
M MohtyF MalardM AbecassisE AertsA S AlaskarM AljurfM AratP BaderF BaronA BazarbachiD BlaiseF CiceriS CorbaciogluJ-H DalleR F DuarteT FukudaA HuynhT MassziM MichalletA NaglerM NiChonghaileT PagluicaChristina PetersF B PetersenP G RichardsonT RuutuB N SavaniE WallhultI Yakoub-AghaE CarrerasPublished in: Bone marrow transplantation (2015)
Sinusoidal obstruction syndrome or veno-occlusive disease (SOS/VOD) is a potentially life-threatening complication of hematopoietic SCT (HSCT). This review aims to highlight, on behalf of the European Society for Blood and Marrow Transplantation, the current knowledge on SOS/VOD pathophysiology, risk factors, diagnosis and treatments. Our perspectives on SOS/VOD are (i) to accurately identify its risk factors; (ii) to define new criteria for its diagnosis; (iii) to search for SOS/VOD biomarkers and (iv) to propose prospective studies evaluating SOS/VOD prevention and treatment in adults and children.